Genetic analysis of TOR complex 2 signaling
Lipid metabolism is regulated by a complex network of genes spanning numerous biological processes and coordinated functions of multiple tissues. We have established Caenorhabditis elegans as a useful...
View ArticleStructural and biochemical characterization of the Saccharomyces cerevisiae...
The 5 AMP-activated protein kinase AMPK) is a master regulator of energy homeostasis. AMPK is activated by a high AMP:ATP ratio, and functions as a metabolic thermostat. By sensing when energy is low,...
View ArticleMolecular characterization of a replication licensing checkpoint
Each and every time a cell divides it must replicate millions of bases of DNA. In order to carry out this large feat, it initiates replication from thousands of sites along the DNA known as origins....
View ArticleIdentification and characterization of physically interacting partners of...
Vitamin A is essential for male reproduction as demonstrated by the sterility of the rats fed with vitamin A-deficient diet. The vitamin A signal is mediated by two families of retinoid receptors,...
View ArticleGenome-wide profiling of mRNA turnover in Saccharomyces cerevisiae
Regulated mRNA turnover is a critical component of the gene expression program. Cells rapidly change their expression profile by modulating the transition between active translation and mRNA decay. In...
View ArticleEarly animal evolution: Insights from genomes and embryos of cnidarians,...
Since the origin of animals &sim；750 million years ago, morphologically diverse animal forms have evolved. Sponges, cnidarians and placozoans are early diverging animal phyla and studies of their...
View ArticleThe role of the Pif1 helicase in inhibition of telomerase at telomeres and...
Telomere length is maintained by the telomerase holoenzyme. Yeast telomerase activity requires the reverse transcriptase subunit Est2, the templating RNA (TLC1) and additional proteins Est1, Est3, and...
View ArticleTarget gene selection in the wingless signaling pathway
Wingless/Wnt family proteins Wg/Wnt) activates the Wg/Wnt signaling pathway in receiving cells that regulates the expression of its target genes through T cell factor TCF). The high mobility group HMG)...
View ArticleThe role of platelet-derived growth factor receptor-expressing fibroblasts in...
Although excessive activation of myofibroblast proliferation and extracellular matrix (ECM) deposition by platelet-derived growth factor-A (PDGF-A) and transforming growth factor beta (TGFbeta)...
View ArticleRecovery of pancreatic beta-cells from nitric oxide-induced damage
Proinflammatory cytokines inhibit pancreatic beta-cell function and induce damage to beta-cell DNA, ultimately resulting in beta-cell death and the development of type I diabetes. While nitric oxide...
View Article
